产品货号：
GS4821
中文名称：
重组人IL-4
英文名称：
Recombinant Human Interleukin-4
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 15.0kDa,a single non-glycosylated polypeptide chain containing 129 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-4(IL-4)is a pleiotropic cytokine that induces differentiation of naive helper T cells(Th0 cells)to Th2 cells and produced by mast cells,activated T cells and bone marrow stromal cells.It has many biological roles,including the stimulation of activated B-cell and T-cell proliferation,and the differentiation of CD4+ T-cells into Th2 cells.It enhances both secretion and cell surface expression of IgE and IgG1 and also regulates the expression of the low affinity Fc receptor for IgE(CD23)on both lymphocytes and monocytes.The human IL-4 has a compact,globular fold,stabilised by 3 disulphide bonds.The human IL-4 shares about 40%a.a.sequence identity with mouse/rat IL-4 and they are species-specific in their activities.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IL-4，IL-4, Human，Recombinant Human Interleukin-4
储存条件：冷冻（-20℃）
概述
Interleukin-4(IL-4)is a pleiotropic cytokine that induces differentiation of naive helper T cells(Th0 cells)to Th2 cells and produced by mast cells,activated T cells and bone marrow stromal cells.It has many biological roles,including the stimulation of activated B-cell and T-cell proliferation,and the differentiation of CD4+ T-cells into Th2 cells.It enhances both secretion and cell surface expression of IgE and IgG1 and also regulates the expression of the low affinity Fc receptor for IgE(CD23)on both lymphocytes and monocytes.The human IL-4 has a compact,globular fold,stabilised by 3 disulphide bonds.The human IL-4 shares about 40%a.a.sequence identity with mouse/rat IL-4 and they are species-specific in their activities.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞98%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.2ng/ml,corresponding to a specific activity of>5.0×106 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1.0 EU/μg of rHuIL-4 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | HKCDITLQEI IKTLNSLTEQ KTLCTELTVT DIFAASKNTT EKETFCRAAT VLRQFYSHHE KDTRCLGATA QQFHRHKQLI RFLKRLDRNL WGLAGLNSCP VKEANQSTLE NFLERLKTIM REKYSKCSS |
相关搜索：重组人IL-4，IL-4, Human，Recombinant Human Interleukin-4